DOI: http://dx.doi.org/10.18203/2349-2902.isj20214023

A rare presentation of gastric gastro-intestinal stromal tumour managed by stomach preserving surgery: a case report

Arun S. Patil, Dnyaneshwar Raut, Aishwarya V. Swami, Khadeija A. Hussain, Kanishk N. Patil

Abstract


Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the alimentary canal that account for 0.1–3% of all gastrointestinal malignancies. Vast majority of these tumors have oncogenic gain-of-function mutations of the KIT receptor tyrosine kinase. The mainstay of treatment is complete surgical resection followed by adjuvant therapy with tyrosine kinase inhibitors (Imatinib). We present a case report of 47 years old male presenting with a large abdominal lump, later diagnosed as a Gastrointestinal stromal tumor and underwent stomach preserving sleeve gastrectomy.


Keywords


GIST, Abdominal lump, Imatinib, DOG1

Full Text:

PDF

References


Sjogren PP, Banerji N, Batts KP, Graczyk MJ, Dunn DH. Rare presentation of a gastrointestinal stromal tumor with spontaneous esophageal perforation: A case report. International Journal of Surgery Case Reports. 2013;4(7):636-9.

Ansari WA, Saha P, Khairatkar R, Gupta M, Raut D, Iralu M. An Unusual presentation of Gastric Gastro intestinal Stromal Tumour: A Case Report.

Roggin KK, Posner MC. Modern treatment of gastric gastrointestinal stromal tumors. World Journal of Gastroenterology: WJG. 2012;18(46):6720.

Fernández JA, Frutos MD, Ruiz-Manzanera JJ. Incidental Gastrointestinal Stromal Tumors (GISTs) and Bariatric Surgery: A Review. Obesity Surgery. 2021;30(11):4529-41.

Heinrich MC, Corless CL. Gastric GI stromal tumors (GISTs): The role of surgery in the era of targeted therapy. Journal of Surgical Oncology. 2005;90(3):195-207.

Yang ML, Wang JC, Zou WB, Yao DK. Clinicopathological characteristics and prognostic factors of gastrointestinal stromal tumors in Chinese patients. Oncology Letters. 2018;16(4):4905-14.

Euanorasetr C. Outcomes and Prognostic Factors of Primary Gastric GIST Following Complete Surgical Resection: A Single Surgeon Experience. J Med Assoc Thai. 2011;94(1).

Stomach Preserving Surgery in Large Exophytic Gastointestinal Stromal Tumour. 2017.

Majinyang S, Ruth YKM, Ahmed S, Sanghvi K, Oo AM, Nath KA, et al. Microscopically Positive Resection Margins in Laparoscopic Gastric GIST Resection May Not Confer a Poorer Prognosis. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2019;29(5):393-8.

Vassos N, Jakob J, Kähler G, Reichardt P, Marx A, Dimitrakopoulou-Strauss A, et al. Preservation of Organ Function in Locally Advanced Non-Metastatic Gastrointestinal Stromal Tumors (GIST) of the Stomach by Neoadjuvant Imatinib Therapy. Cancers. 2021;13(4):586.

Çaynak M, Özcan B. Laparoscopic Transgastric Resection of a Gastrointestinal Stromal Tumor and Concomitant Sleeve Gastrectomy: a Case Report. Obesity Surgery. 2020;30(4):1596-9.

Morinaga N, Sana A, Katayama K, Suzuki K, Kamisaka K, Asao T, et al. Laparoscopic transgastric tumor-everting resection of the gastric submucosal tumor located near the esophagogastric junction. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2004;14(6):344-8.

Gold JS, Gönen M, Gutiérrez A, Broto JM, García-del-Muro X, Smyrk TC, et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. The Lancet Oncology. 2009;10(11):1045-52.

Joensuu H, Eriksson M, Hall KS, Hartmann JT, Pink D, Schütte J, et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial. JAMA - Journal of the American Medical Association. 2012;307(12):1265-72.