DOI: http://dx.doi.org/10.18203/2349-2902.isj20221426

Cerebellopontine angle tumour in a case of metastatic carcinoma breast: a diagnostic dilemma

Avneet Kaur, Suman Kharkwal, Sushanta Sarkar, Pawan Kalra

Abstract


Tumours of the cerebellopontine angle are mostly vestibular schwannomas with metastasis being a rare diagnosis. But, metastasis if present, are usually from a breast or a lung primary. We presented a case of a 67 year old postmenopausal lady with luminal. A carcinoma left breast who developed a recurrence on aromatase inhibitor with bone metastasis. She also presented with a cerebellopontine angle tumour which, because of its unusual presentation, presence of a recurrent breast disease with metastasis and mutation testing, raised the suspicion of a brain metastasis but was finally confirmed to be a vestibular schwannoma by histopathology.


Keywords


Cerebellopontine angle tumour, Breast cancer, Multiple primary, Recurrence, p53

Full Text:

PDF

References


Testori A, Cioffi U, Simone MD, Bini F, Vaghi A, Lemos AA, et al. Multiple primary synchronous malignant tumors. BMC Res Notes. 2015;8:730.

Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2004;22(14):2865-72.

Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. J Clin Oncol. 2004;22(17):3608-17.

Lee YT. Breast carcinoma: pattern of metastasis at autopsy. J Surg Oncol. 1983;23(3):175-80.

Tsukada Y, Fouad A, Pickren JW, Lane WW. Central nervous system metastasis from breast carcinoma. Autopsy study. Cancer. 1983;52(12):2349-54.

Koniali L, Hadjisavvas A, Constantinidou A, Christodoulou K, Christou Y, Demetriou C, et al. Risk factors for breast cancer brain metastases: a systematic review. Oncotarget. 2020;11(6):650-69.

Tsao MN, Lloyd N, Rebecca KS, Chow E, Rakovitch E, Laperriere N, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2012;2012(4):003869.

Leone JP, Leone BA. Breast cancer brain metastases: the last frontier. Exp Hematol Oncol. 2015;4:33.

Brackmann DE, Bartels LJ. Rare tumors of the cerebello-pontine angle. Otolaryngol Head Neck Surg (1979). 1980;88(5):555-9.

Hill BA, Kohut RI. Metastatic adenocarcinoma of the temporal bone. Arch Otolaryngol. 1976;102(9):568-71.

Rivlin N, Brosh R, Oren M, Rotter V. Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes Cancer. 2011;2(4):466-74.

Alsner J, Yilmaz M, Guldberg P, Hansen LL, Overgaard J. Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients. Clin Cancer Res. 2000;6(10):3923-31.

Ozlem Y, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol. 2014;5(3):412-24.

Yamamoto M, Hosoda M, Nakano K, Jia S, Hatanaka KC, Takakuwa E, et al. p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors. Cancer Sci. 2014;105(1):81-8.

Voltan R. p53 and merlin tumor suppressors: Two of a kind. E Bio Med. 2018;37:23-4.