DOI: http://dx.doi.org/10.18203/2349-2902.isj20222060

Stem cells in the treatment of surgical wounds

Patricia Sofia Elguezabal Riojas, Moisés Morales Espinosa

Abstract


One surgical method per year for every 22 people is developed. Stem cells are those that are known to have an important and unique potential for renewal. They have the functionality to make a difference in many different cell types throughout the early stages of life and growth. Skin is the largest organ in the body and has a variety of functionalities. Compartments of the dermis, epidermis and hair follicles house stem cells important for homeostasis and regeneration of the dermis. These stem cells contribute to wound repair, which results in total tissue replacement and damaged tissue function. The authors agree on the theoretical role of stem cells in the treatment of surgical wounds. Treatment must be individualized, and variables such as adverse effects must be taken into account, however, it seems to be a promising therapeutic.


Keywords


Stem cells, Surgical wound, Therapy

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References


Gillespie BM, Walker RM, Mcinnes E, Moore Z, Eskes AM, O'connor T, et al. Preoperative and postoperative recommendations to surgical wound care interventions: A systematic meta-review of Cochrane reviews. Int J Nurs Studies. 2020;102:103-9.

Mani C, Reddy PH, Palle K. DNA repair fidelity in stem cell maintenance, health, and disease. Biochim Biophys Acta Mol Basis Dis. 2020;1866(4):165444.

Özmert E, Arslan U. Management of retinitis pigmentosa by Wharton’s jelly derived mesenchymal stem cells: preliminary clinical results. Stem Cell Res Ther. 2020;11(1):25.

Liu Y, Chen SJ, Li SY, Qu LH, Meng XH, Wang Y, et al. Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients. Stem Cell Res Ther. 2017;8(1):1186-9.

Foltz LP, Clegg DO. Patient-derived induced pluripotent stem cells for modelling genetic retinal dystrophies. Prog Retin Eye Res. 2019;68:54-66.

Millán-Rivero JE, Nadal-Nicolás FM, García-Bernal D, Sobrado-Calvo P, Blanquer M, Moraleda JM, et al. Human Wharton’s jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors. Sci Rep. 2018;8(1):16299.

Ullah I. Human mesenchymal stem cells current trends and future prospective. Biosci Rep. 2015; 35(2):e00191.

Singh G. Cytokine regulation of stem cells. Peer J. 2016;23:31-8.

Kim W-S, Park B-S, Sung J-H, Yang J-M, Park S-B, Kwak S-J, et al. Wound healing effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007;48(1):15-24.

Kim W-S, Park B-S, Sung J-H. The wound-healing and antioxidant effects of adipose-derived stem cells. Expert Opinion Biol Ther. 2009;9(7):879-87.

Alcayaga-Miranda F, Cuenca J, Khoury M. Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies. Front Immunol. 2017;8:23-8.

Esfandiyari R, Halabian R, Behzadi E, Sedighian H, Jafari R, Fooladi AAI. Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells. Heliyon. 2019;5(10):21-7.

Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. United States of America: Elsevier; 2019.

Matsumoto D, Sato K, Gonda K, Takaki Y, Shigeura T, Sato T, et al. Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng. 2006; 12(12):3375-82.

Li Y, Zhang W, Gao J, Liu J, Wang H, Li J, et al. Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway. Stem Cell Res Ther. 2016;7(1):102.