Published: 2022-08-26

Low gastrointestinal tract bleeding secondary to low-grade gastrointestinal stromal tumor: case report

Yuri Jiménez Caprielova, Adrián Aguilar Izaguirre, Eduardo Israel Vega Chavarria, Samuel Rodríguez Gómez Arenas, Yamir Ahmed Nacud Bezies


Gastrointestinal stromal tumors (GIST) are neoplasms of mesenchymal origin. We present the case of a patient with low gastrointestinal tract bleeding secondary to a gastrointestinal stromal tumor, as well as her diagnostic clinical approach in a third-level medical unit, as well as a brief review of the literature. The treatment of this neoplasm is surgical and ideally consists of complete resection with negative margins (R0). GISTs mostly affect patients between 4-6 decades of life with a slight predominance in women, with the stomach and small intestine being the most frequently affected organs. The immunohistochemical study shows positivity for c-KIT and CD34 in 100% and 63% of cases. The treatment is surgical which usually by maintaining free margins is curative


GIST, Gastrointestinal bleeding, Neoplasm

Full Text:



Kelly CM, Gutierrez Sainz L, Chi P. The management of metastatic GIST: current standard and investigational therapeutics. J Hematol Oncol. 2021;14(1):1-12.

Hallak YO, Karajeh O, Rivas H, Helling K. Incidental Gastrointestinal Stromal Tumors (GIST) During Laparoscopic Sleeve Gastrectomy Procedures: a Retrospective Study. Obesity Surgery. 2022;32(1):3-7.

Chandrasekaran T, Sahid NA, Maiyauen TK. Synchronous Gastrointestinal Stromal Tumor (GIST) with pancreatic adenocarcinoma: A case report. Ann Med Surg. 2022;77:103588.

Gevorkian J, Le E, Alvarado L. Trends and outcomes of minimally invasive surgery for gastrointestinal stromal tumors (GIST). Surgical Endoscopy. 2022;1-10.

Liu H, Santanello A, Jimenez M, Kumthekar N. Jejunal Gastrointestinal Stromal Tumor (GIST) as a Rare Cause of GI Bleed: A Case Report. Cureus. 2022;14(4).

Ekanayake L, Kumar A, Triplett D, Usman N, Ali S. S3590 Gastric GIST Presenting as Melena in a Hemodynamically Unstable Patient: A Case Report. Am J Gastroenterol. 2021;116(1):S1472.

Pih GY, Ahn JY, Choi JY. Clinical outcomes of tumor bleeding in duodenal gastrointestinal stromal tumors: a 20-year single-center experience. Surgical Endoscopy. 2020;35(3):1190-201.

Fan X, Han H, Sun Z. Prognostic Value of Bleeding in Gastrointestinal Stromal Tumors: A Meta-Analysis. Technol Cancer Res Treat. 2021;20:15330338211034259.

Díaz-Oliva SE, Aguilera-Matos I. Gastrointestinal stromal tumor as an unusual cause of gastrointestinal bleeding in pediatrics Esophageal eosinofilia View project. J Med Case Rep Case Series. 2021;3(1).

Kundapur P, Ilnyckyj A. A126 GIST-glue in stromal tumor. J Can Assoc Gastroenterol. 2021;4(1):108-9.